Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.
Obsessive master thief, Neil McCauley leads a top-notch crew on various daring heists throughout Los Angeles while determined detective, Vincent Hanna pursues him without rest. Each man recognizes and respects the ability and the dedication of the other even though they are aware their cat-and-mouse game may end in violence.
Threats from sinister foreign nationals aren't the only thing to fear. Bedraggled college professor Michael Faraday has been vexed (and increasingly paranoid) since his wife's accidental death in a botched FBI operation. But all that takes a backseat when a seemingly all-American couple set up house next door.
Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.
Homicide detective John Hobbes witnesses the execution of serial killer Edgar Reese. Soon after the execution the killings start again, and they are very similar to Reese's style.
A police detective falls in love with the woman whose murder he's investigating.
Private Investigator Philip Marlowe is hired by wealthy General Sternwood regarding a matter involving his youngest daughter Carmen. Before the complex case is over, Marlowe sees murder, blackmail, deception, and what might be love.
After a break-in at their house, a couple gets help from one of the cops that answered their call. He helps them install the security system, and begins dropping by on short notice and unofficial patrol, and spends a lot of time discussing the couple's problems with the wife. The husband begins wondering if they're getting too much help.